Since the first case of HIV was detected in 1988, an epidemic of HIV in Nepal rose sharply in the mid1990s and was in peak during mid-2000s. Nepal has transitioned from ‘low-level epidemics’ to ‘concentrated epidemic’ with rapid spread among key population, i.e. Female Sex Workers (FSW), Men having sex with Men and Transgender (MSM/TG), People who Inject Drugs (PWID) (Male and Female), Male Labor Migrants (MLM) and their spouses and Clients of Sex Workers (CSW). The national response to HIV is guided by “National Policy on HIV and STI, 2011” and “Nepal HIV vision 2020” with a vision of ending the AIDS epidemic as a public health threat in Nepal by 2030. The national consolidated SI guideline aims to design an appropriate framework for measuring progress of Nepal HIV Strategic Plan targets and indicators at different levels, i.e. impact, outcome and output level, including definitions of core indicators and specifications for data collection and provide a roadmap for data sources, data collection, analysis and its use for improvement in implementation of the programme.