In Nepal an HIV case was first detected in 1988. The prevalence of HIV in adults is 0.17 percent in 2016. The National Centre for AIDS and STD Control (NCASC) has taken the lead role in lowering the rate of HIV infections throughout Nepal. HIV prevalence has reduced significantly during the last decade due to effective targeted interventions among key populations and greater enrolment in treatment. The NCASC, with technical assistance of key stakeholders, has been able to follow the “test and treat approach” to reach the global target (90-90-90).